A psychedelic more powerful than DMT (dimethyltryptamine) is hard to come across, especially 5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine or O-methyl-bufotenin). This substance mimics neurotransmitters like serotonin to produce the majority of its psychedelic effects because it is a tryptamine-based psychedelic. 5-MeO-DMT is a naturally occurring substance that is mostly found in the toad species Bufo alvarius, often known as the Sonoran Desert Toad or the Colorado River Toad. It’s also widely used in synthetic form, which can be inhaled (snorted), vaped, or smoked.
Although the effects of this psychedelic are infamously short-lived, it acts quickly. You can enter a timeless hyperspace with a quick rip on 5-MeO-DMT, where users frequently claim conversing with machine elves. Most users return to reality within 45 minutes, even though the experience can seem like a lifetime. A journey on 5-MeO-DMT can significantly alter your perspective, no matter how brief. The power of 5-MeO is a mystery that may both humble and inspire. It is amazing, terrifying, and occasionally healing.
5-MeO-DMT: Specs & Technical Details
| Active Ingredient | 5-MeO-DMT |
| Level of Risk | Low |
| Most Common Side Effects | Ego-dissolution, Ineffable |
| Duration of Effects | Peak 10–30 min, 1-hour total |
| Legality | Varies, unscheduled in some areas |
Guidelines for the Responsible Use of 5-MeO-DMT
- 🐍 I can see why psychedelics should be respected.
- ⚖️ I am aware of the regulations pertaining to psychedelics in my nation and state.
- 🍄 The smoked “average” dose of synthetic 5-MeO-DMT is 8–12 mg, which I am familiar with and confident with.
- 🧪 I used a drug-testing kit to test a sample of the substance I use.
- 💊 I’m not combining 5-MeO-DMT with any drugs or other things.
- 🏔️ I’m with individuals I trust in a secure and comfortable setting.
- 🐺 One of my group members, a trip sitter, is responsible and sober.
- ⏳ After the trip, I have nothing significant planned.
- 🧠 My mental state is sound and healthy.
What’s the Difference Between N,N-DMT & 5-MeO-DMT?
Before going further, it’s important to clarify that there are multiple DMT analogs, each with distinct characteristics.
The term “DMT” most often refers to N,N-DMT, the primary psychoactive compound in ayahuasca and changa.
Chemically, the difference between N,N-DMT and 5-MeO-DMT lies in the addition of an oxygen molecule on the indole ring of 5-MeO-DMT.
Although both substances share similarities — such as rapid onset and intense effects — the 5-MeO-DMT experience extends beyond the vivid geometric visuals typical of N,N-DMT.
Experiences with 5-MeO-DMT are frequently described as feelings of unity, non-duality, or being beyond verbal explanation. Language ultimately falls short in conveying the depth of what 5-MeO-DMT can reveal. Many users agree that 5-MeO-DMT propels consciousness even further beyond ordinary reality than N,N-DMT.
Many people associate 5-MeO-DMT with its amphibian source — the Bufo alvarius toad, also called the Sonoran Desert Toad or Colorado River Toad.
These toads inhabit limited regions in northern Mexico and the southwestern United States. They spend most of the year underground and surface at night during summer rainfall to reproduce — a period commonly known as “toad season.” During this time, increasing numbers of individuals seek out the toad’s potent secretions.
Growing demand has resulted in overharvesting, placing the species at risk in its natural environment.
Recent reports have described rival groups competing over scarce toad populations. Some toads are sold online for prices as high as $1,000. Concerns have also been raised about the potential harm caused during venom extraction. Bufo alvarius releases a milky white venom from glands on its head as a defensive response.
Once collected, the venom is dried and later smoked. It contains a mixture of other potentially active compounds, including bufotenin (5-HO-DMT), which may contribute to the overall experience through what is known
5-MeO-DMT Snuffs: Epená, Yopo & Cohoba
Although smoking toad venom is the most well-known method of consuming 5-MeO-DMT, the compound exists naturally in many plants and certain Amanita mushrooms.
Whether the use of bufo venom is ancient or modern remains unclear, but ingestion of 5-MeO-DMT from plant sources dates back thousands of years. Snuff use is one of the earliest confirmed forms of psychoactive substance consumption. Archaeological findings such as ancient pipes and snuff trays in South America support its widespread historical use.
Myths recorded by Schultes in Plants of the Gods describe snuffs being stolen from the Sun God by his daughter and gifted to humans to allow communication with the spirit realm. Amazonian snuffs often consist of multiple plant species working together synergistically.
These snuffs are known by many names across different tribes and regions, and not all contain 5-MeO-DMT — for example, tobacco-based rapé.
In Pharmacotheon, Jonathan Ott describes a snuff known as Epená, sometimes derived from Virola species. The preparation involved scraping red resin from the tree’s inner bark, drying or boiling it, and processing it into a resin that was ground and sometimes combined with ash. The bark primarily contains 5-MeO-DMT and N,N-DMT, with some varieties also containing MMT, 6-MeO-DMT, trace beta-carbolines, and other compounds.
Yopo Plant (Anadenanthera peregrina)
Yopo is a snuff made from the seeds of Anadenanthera peregrina or Anadenanthera colubrina. Similar snuffs are used throughout South America and the Caribbean, where they are known as Cohoba.
While commonly believed to contain mainly 5-MeO-DMT and N,N-DMT, Jonathan Ott has suggested that bufotenin (5-HO-DMT) may be the primary active compound in yopo. Given the wide variety of plants used, isolating effects to a single compound is difficult.
Oral & Sublingual 5-MeO-DMT
There has long been uncertainty regarding whether 5-MeO-DMT is orally active.
Ethnobotanist Richard Evans Schultes first documented oral preparations, later studied by Dennis McKenna. Initial attempts failed to replicate observed effects. Sasha Shulgin also reported oral inactivity in TiHKAL.
Later, Jonathan Ott documented oral effects using a 30 mg capsule, though the experience was significantly milder. Ott experimented with harmala alkaloids to increase effects — a combination considered potentially dangerous and not recommended.
Synthetic 5-MeO-DMT
As access to toads and traditional snuffs has declined, synthetic 5-MeO-DMT has become increasingly common. The compound was first synthesized in 1936 by Japanese chemists Toshio Hoshino and Kenya Shimodaira from Anadenanthera peregrina seeds.
Today, many people obtain it from online research chemical suppliers or manufacturers.
Synthetic 5-MeO-DMT typically appears as a white, yellow, or orange crystalline powder.
What Is the Dosage of 5-MeO-DMT?
Effective dosage varies depending on method of administration — smoked, vaporized, snorted, swallowed, injected, or rectal — as well as the form used.
Snuffs sourced from the Amazon should only be administered by experienced practitioners due to unpredictable potency.
James Oroc notes in Tryptamine Palace that smoked doses should be adjusted in 2 mg increments. Identifying the minimum effective dose helps retain memory of the experience, as excessive doses can result in a “white hole” with no recollection.
1. Bufo Toad Venom Dosage
Typical doses of raw Bufo venom range from 10–60 mg, smoked or vaporized.
Alkaloid content varies widely. Shulgin reported concentrations up to 15%, while other sources suggest 10–30%. Due to this variability, effects differ greatly between individuals. Starting low and working upward with experienced guidance is essential.
2. Synthetic 5-MeO-DMT Dosage
Synthetic 5-MeO-DMT is commonly smoked but may also be snorted, taken rectally, or used orally or sublingually. Smoking produces rapid onset and brief effects, while other methods result in slower, longer experiences.
Consider whether the compound is HCl or freebase before choosing a method. Freebase is typically smoked, while HCl is preferred for snorting.
| Dose Level | Smoked/Vaped | Snorted |
|---|---|---|
| Threshold | 1–5 mg | 3–5 mg |
| Low | 5–7 mg | 5–10 mg |
| Standard | 8–12 mg | 8–15 mg |
| High | 13–20 mg | 10–25 mg |
3. Other Routes of Administration
Less common methods include:
- Sublingual: 10 mg
- Oral: 20–30 mg
- Rectal: 20–30 mg
What Does 5-MeO-DMT Feel Like?
Effects vary by dose and method. Lower doses may enhance visual brightness and patterns, accompanied by bodily heaviness. Higher doses often result in complete separation from physical reality.
Common experiences include merging with white light, encountering divine or ancestral presences, hearing a resonant sound, and losing all sense of time. These experiences can be emotionally powerful and transformative.
How Long Does 5-MeO-DMT Last?
5-MeO-DMT is known for its brief duration, often referred to as a “business trip.”
- Smoked/Vaped: Onset within seconds, peak 5–20 minutes, full return within 45–60 minutes
- Snorted: Onset in minutes, total duration about one hour
- Oral: Delayed onset with lingering aftereffects
The body metabolizes the substance quickly, making prolonged intoxication impossible.
Common Features of 5-MeO-DMT include:
- Fractals
- White light
- “The Sound”
- Spirits, God, Ancestors, Love
- Oneness, ego-dissolution, out-of-body
- Overwhelm, losing control, “too much”
- Timelessness
How Long Does 5-MeO-DMT Last?
5-MeO-DMT is notoriously short-acting. This has led many to refer to this drug as a “business trip.” Most intake methods don’t last longer than about 45 minutes. However, there’s some nuance here depending on how much you took and how you took it.
1. Smoked or Vaped
Smoked or vaporized, 5-MeO-DMT takes effect within seconds.
At high enough doses, the sense of disconnect from one’s body lasts 5-20 minutes.
After this peak, the effects rapidly disappear, and within 45 minutes to an hour, full sobriety settles in.
The body metabolizes 5-MeO-DMT very rapidly, so you will never get stuck in 5-MeO-DMT mode.
While the effects don’t last long, it’s best to give yourself some time to rest and process 5-MeO-DMT, as the experience can be a lot to take in.
2. Snorted or Swallowed
When snorted, the effects begin acting within minutes, peaking around 10-20 minutes. After 45 minutes, the effects lessen, and the entire experience lasts about an hour for most people.
Depending on the preparation, particularly with various snuffs, some people experience lingering effects for up to three hours later.
Oral consumption is similar but with a 30-minute delay. The effects kick in about 40–50 minutes after taking it, remain active for about 20-30 minutes, and taper off over the next hour. Some lingering effects may remain for several hours.
How Strong is 5-MeO-DMT Compared To Other Psychedelics?
5-MeO-DMT is 4-5 times stronger than N-N,DMT — according to Jonathan Ott in Pharmacotheon.
It’s also stronger than most other psychedelics. Even high doses of psilocybin (the active ingredient in magic mushrooms) are about 10% as strong as a standard dose of 5-MeO-DMT. Mescaline (the active ingredient in Peyote and San Pedro Cacti) is about the same.
Even very powerful psychedelics like salvinorin A (the active ingredient in Salvia divinorum) are notably milder in the depth of experience.
Technically speaking, the lysergamide family (LSD, AL-LAD, PRO-LAD, LSZ, ETH-LAD, 1P-LSD, and others) are stronger than 5-MeO-DMT, but only when you compare the dose. The effects of these compounds are far less intense than 5-MeO-DMT.
The standard oral dose range for lysergamides like LSD is between 80 and 120 mcg. Compare this to around 20 or 30 mg for 5-MeO-DMT. This makes LSD significantly stronger, but even in very high doses, LSD doesn’t completely blast apart our perceptions of reality and time the way 5-MeO-DMT can.
Is 5-MeO-DMT Safe?
While you’re unlikely to die from an overdose on 5-MeO-DMT, it can still be dangerous if misused.
The usual psychedelic cautionary notes apply — people with physical health problems like heart conditions might be at risk. Those with mental health concerns like schizophrenia, bipolar, or other diagnoses should not use 5-MeO-DMT. Consult with a trusted professional if you’re uncertain.
Side Effects of 5-MeO-DMT
Side effects like seizures, self-harm, violent physical releases, and psychosis have occurred in some people without warning. There are some reports of people dying from choking on vomit after taking 5-MeO-DMT by themselves.
Addiction & Abuse
Addiction is also rare but not unheard of — especially with the advent of DMT vape pens, many users find themselves puffing on DMT compulsively. This can significantly increase the risk of mental health disorders like psychosis or hallucinogen-persisting perception disorder (HPPD).
The Dangers of Tripping Solo on 5-MeO-DMT
Using 5-MeO-DMT without a tripsitter is not recommended. During the experience, a loss of bodily control is common. Having someone nearby to protect you from harm while under the effects is a necessity. This person should be a trained facilitator who knows CPR.
Prescription Drug Interactions
Do not mix 5-MeO-DMT with prescription drugs, including SSRIs (selective serotonin reuptake inhibitors), MAOIs (monoamine oxidase inhibitors), or other antidepressants or antipsychotics.
Anyone mixing 5-MeO-DMT with harmala alkaloids should be extremely careful, as these can also cause potentially lethal consequences.
5-MeO-DMT Overdose
While rare, an overdose on 5-MeO-DMT is possible, and there have been reports of this happening in the past. Shulgin includes a harrowing account in THiKAL of needing to resuscitate someone who stopped breathing after taking too much. There are also concerns about mixing 5-MeO-DMT with ayahuasca, with at least one death reported in the literature [12].
Long-Term Side Effects of 5-MeO-DMT
Long-term side effects from 5-MeO-DMT are rare and can normally be avoided through intentional use and adequate integration following the experience.
One of the most common persisting side effects is anxiety or a vague sense that “something” is wrong.
Difficulty sleeping or “grounding” is also not uncommon after taking 5-MeO. Some practitioners encourage eating heavy foods for a few weeks after the experience to offset this effect.
There is also the potential for flashbacks, known as “reactivations.” This isn’t a rumor; it’s well documented in research, but the exact cause is unknown [13]. Some subjects report quick flashes, while others report a full-blown experience. Reactivations can last anywhere from a few seconds to a week.
Testing Your 5-MeO-DMT For Purity
The Erlich and Hoffman regent tests are the best way to test 5-MeO-DMT samples for purity.
It’s always wise to test a sample of your drugs BEFORE you take them. But remember that testing doesn’t guarantee safety or purity and is best used to rule out certain dangerous compounds.
The Erlich test cannot confirm the presence of 5-MeO-DMT but is helpful to distinguish if you do, in fact, have an indole (and not something dangerous like an N-Bombs).
A successful test will turn a purplish color; view the video here.
To further distinguish between tryptamines, a Hoffman reagent test works well. For example, if you are unsure if you have N,N-DMT, or 5-MeO-DMT. For 5-MeO-DMT, the Hoffman test will turn green. If it is N,N,DMT, a yellowish color will appear instead.
Is 5-MeO-DMT Legal?
The legality of 5-MeO-DMT varies. It was not banned alongside other psychedelics in the 70s as it was not as popular then. However, since its reputation has grown, 5-MeO-DMT has been a Schedule 1 substance in the United States since 2011.
Other countries have yet to ban this substance — most notably Canada, where 5-MeO-DMT is readily sold online and in some dispensaries.
Notable countries for access (though not necessarily legal) include:
How Does 5-MeO-DMT Work?
5-MeO-DMT is a serotonergic psychedelic. This means it primarily binds to the serotonin receptors — most notably the 5HT1A, 5HT2A, and 5HT2C receptors.
5-MeO-DMT has a methoxy group attached to its primary ring structure (known as an indole ring). This methoxy group may create a higher receptor binding affinity than its DMT relatives. This is why it works so rapidly and powerfully compared to other forms of DMT.
Some studies also show interesting and promising data regarding the use of 5-MeO DMT for various mental health conditions, including [14]:
- Anxiety
- Depression
- Immunomodulation
- Inflammation
- Life satisfaction
- Mindfulness
- Neuroendocrine effects
- Obsessive-compulsive disorder
- PTSD
- Stress
- Substance use disorder
5-MeO-DMT FAQS
If we still haven’t answered your question, email us at sales@psychedelics.my
1. Can You Really Lick Toads?
You can lick toads, but don’t expect to get high, only sick. There are hundreds of species of Bufo toads, but we only know that Alavruis contains enough alkaloids for a psychedelic experience. While it’s possible to eat toad venom for psychoactive effects, keep in mind that toads secrete venom as a defense mechanism — it’s supposed to make you feel uncomfortable. There are reports of animals and children having fatal responses to bufo venom.
2. Where Can I Find a 5-MeO-DMT Retreat?
While unscheduled in countries like Canada or parts of Europe, it may be difficult to find retreats openly offering 5-MeO-DMT. Mexico and some parts of South America have fairly open use of 5-MeO-DMT with a growing number of retreat options. Some practitioners perform individual and group 5-MeO-DMT ceremonies. Be sure to vet any practitioner thoroughly.
3. Where Can I Buy 5-MeO-DMT Online?
Depending on your location, it is possible to buy 5-MeO-DMT in areas where it is not a scheduled substance. There are established options in Canada and some parts of Europe, but be aware that various jurisdictions will treat unscheduled drugs differently. Unscheduled is more of a “grey area” than being legal or decriminalized, so research carefully.
4. Does 5-MeO-DMT Cause Flashbacks?
Yes, 5-MeO-DMT does sometimes have persisting effects called reactivations. While this is not technically considered the same as hallucination persisting perception disorder (HPPD), which is a serious medical condition, a significant number of people have reported having brief glimpses or very strong feelings that continued for some time after 5-MeO-DMT. Exactly why this happens is unclear and may relate to too-high or repeated uses in one sitting.
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